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KMID : 1101420160480030210
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Korean Journal of Clinical Laboratory Science
2016 Volume.48 No. 3 p.210 ~ p.216
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The Prevalence of Plasmid-Mediated Quinolone Resistance Genes among CTX-M-14 Producing Escherichia coli Strains Isolated from a University Hospital in the Chungcheong Province
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Sung Ji-Youn
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Abstract
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Recently, there has been a considerable increase in the prevalence of CTX-M type extended-spectrum β-lactamase (ESBL)-producing E. coli isolates worldwide, including Korea. To investigate the ESBL genes in the E. coli strains isolated from a university hospital in the Chungcheong area, a study was conducted using PCR amplification and nucleotide sequence analysis of the amplified products to detect the plasmid mediated quinolone resistance (PMQR) genes in ESBL producing E. coli isolates. The number of CTX-M-14 producing isolates was 25 (16.0%) isolates, and of them, 9 (5.8%) isolates also produced CTX-M-15. All CTX-M type ESBL producing E. coli isolates showed resistance to cefotaxime. Twelve (48%) CTX-M type ESBL producing E. coli isolates contained the PMQR genes, 8 contained qnrS1, and 8 contained aac(6’)-Ib-cr. Four isolates harbored both qnrS1 and aac(6’)-Ib-cr genes. In our study, we confirmed that the plasmid mediated antimicrobial resistant determinants?the ESBL and PMQR genes?were distributed in the E. coli isolates. To prevent further spreading of the resistant genes among the E. coli isolates, consistent effort is required to investigate and monitor the resistant genes.
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KEYWORD
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CTX-M type, Extended-spectrum β-lactamase, Plasmid mediated quinolone resistance, E. coli
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